Clinical evaluation of Dengue and identification of risk factors for severe disease in Bangladesh.
CoE-SISU
Year: 2014
IRB Number: 2014-100
Organaisation: BRAC JPGSPH
PI: Professor Malabika Sarker
Objective:Primary Objectives
● To analyse clinical data and laboratory sample parameters to differentiate between dengue and non-dengue illness within the first 72 hours of fever for predicting the progression of dengue fever to more severe disease course, with the overall aim of developing a robust case definition for dengue.
● To identify virological correlations of severe dengue – in particular to assess plasma viremia and NS1 antigenemia within the first 72 hours of fever in patients with confirmed dengue.
● To identify early serological correlations of severe dengue, in order to characterize differences between severe and uncomplicated disease.
● To identify other infectious agents manifesting similar primary signs and symptoms as Dengue pathogenesis with the help of blood culture.
Secondary Objectives
● To evaluate practical application of the original (WHO 1997) and the new dengue classification schemes (WHO 2009).
● To use the data to update the guidelines for Dengue risk factors proposed by WHO.
Donor: International Research Consortium on Dengue Risk Asses, University of Heidelberg, Germany
Research Reports
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