Established in 2016, the main objective of the CoE-SISU is to timely generate and embed knowledge related to healthcare practice. The Centre aims to bridge gaps to allow successful scaling up and implementation of interventions by focusing on testing different methodologies, generating evidence-based interventions and innovations, and translating them into standard protocols for policy-makers in Bangladesh. Research conducted at the Centre reviews potential evidence of successful interventions that can showcase the application of science of implementation for scaling-up. Guidelines and policy briefs are produced for policymakers on implementation of various health programmes and scale-up in Bangladesh. Advocacy efforts include the development of communication materials to showcase successfully implemented or scaled up programmes. Training and short courses are offered under the Centre on implementation research and, monitoring and evaluation to build capacity of development professionals, implementers, researchers and government officials.